Fig. 1: Serum EMC10 levels in white and Chinese Han cohorts.

A Serum EMC10 levels in white human study participants with leanness (n = 27), overweight (n = 20) and obesity (n = 160). B Serum EMC10 levels in Chinese Han human study participants with leanness (n = 32), overweight (n = 115) and obesity (n = 39). Serum EMC10 levels are presented as box (median with interquartile range) and whisker (1.5x interquartile range) plots. Comparisons among 3 groups of participants were performed by one-way ANOVA with Fisher’s post hoc test, and then multiple comparisons were performed using LSD-t test. A two-sided P-value of <0.05 was considered as significant. C Correlation of serum EMC10 levels with BMI in the white cohort shown in panel A (n = 207). D Correlation of serum EMC10 levels with BMI in the Chinese Han cohort shown in panel B (n = 186). E Correlation of serum EMC10 levels with BMI in a white weight-loss cohort (n = 100). The correlation analyses were performed using Pearson’s bivariate correlation. F–N Correlation of serum EMC10 levels with GIR (glucose infusion rate), FINS (fasting plasma insulin), FPG (fasting plasma glucose), HbA1c, FFA (serum free fatty acid), serum leptin and adiponectin, and subcutaneous (SC) fat area and visceral (VIS) fat area, respectively, in white human study participants who underwent euglycemic-hyperinsulinemic clamp (n = 17). The correlation analyses were performed using Spearman’s rank correlation analysis. Source data are provided in the Source Data file.