Fig. 5: Computational simulation of long bone shaping during development and regeneration. | Nature Communications

Fig. 5: Computational simulation of long bone shaping during development and regeneration.

From: Altered developmental programs and oriented cell divisions lead to bulky bones during salamander limb regeneration

Fig. 5: Computational simulation of long bone shaping during development and regeneration.The alt text for this image may have been generated using AI.

A Differences in shape between normally developing (left) and regenerated (right) limb cartilages of the larval Pleurodeles waltl. B Long bone represented by a 3D cylinder. The geometrical and material properties used are specified. C Tissue growth is described as region-specific internal pressures. Tissues are subdivided into different regions, as shown in the scheme (B). Two configurations of internal pressures are applied for modelling normal growth (left) and regeneration (right). D Snapshots of the internal tissue growth simulation for the development (left) and regeneration (right) of the long bone shape.

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