Fig. 1: Shared genetic/genomic associations between psoriasis and CAD.
From: Shared genetic risk factors and causal association between psoriasis and coronary artery disease
a Heatmap of genetic correlations between psoriasis, CAD and six other traits, calculated by applying linkage disequilibrium score regression (LDSC) to summary statistics from the UK Biobank. The color scale indicates genetic correlation (rg), from strongly negative (purple) to strongly positive (yellow). *FDR < 0.01, **FDR < 1 × 10−10, ***FDR < 1 × 10−20. b Venn diagram illustrating the number of shared and distinct genes, with overall association score >0.1 in OpenTargets, involved in psoriasis and CAD. Examples of shared and distinct genes are overlaid; notably many of the shared genes are responsible for immune response. c Manhattan plot of shared (same direction of effect) psoriasis/CAD TDMA signals, showing markers that are more significant in TDMA than for either trait. The three loci we identified that are suggestive significant (p < 1 × 10−4) for both traits (meeting all our criteria) are highlighted in red. d Manhattan plot of opposing (opposite direction of effect) psoriasis/CAD TDMA signals, showing markers that are more significant in TDMA than for either trait. The locus we identified as suggestive significant (p < 1 × 10−4) for both traits (meeting all our criteria) are highlighted in blue. e Bar plot of the proportion of annotations, from GARFIELD enrichment analysis on TDMA outside the MHC, that are significant in each category. Notably, the Blood/Immune category has highest proportion of significant annotations, demonstrating an immunological basis for the shared genetics between psoriasis and CAD. f Grouped bar plot indicating the number of markers in 95% Bayesian credible intervals (BCI) calculated for psoriasis, CAD and TDMA at each locus. TDMA reduces the number of markers in the BCI for all for loci compared to either trait, thus facilitating improved fine-mapping.
