Table 2 Results for Mendelian randomization

From: Shared genetic risk factors and causal association between psoriasis and coronary artery disease

 

Num. markers

Psoriasis

CAD

 

IVW

Median

Mode

MR-RAPS

IVW

Median

Mode

MR-RAPS

 

OR

P

OR

P

OR

P

OR

P

OR

P

OR

P

OR

P

OR

P

Psoriasis

184

—

—

—

—

—

—

—

—

1.01

0.14

1.00

0.64

1.00

0.91

1.01

0.09

CAD

448

1.14

6.3 × 10−4

1.16

3.6 × 10−3

1.45

0.02

1.13

2.2 × 10−3

—

—

—

—

—

—

—

—

BMI

969

1.48

1.5 × 10−9

1.38

1.0 × 10−3

1.96

0.08

1.50

2.2 × 10−9

1.51

5.1 × 10−71

1.52

1.6 × 10−61

1.45

2.8 × 10−4

1.51

1.6 × 10−69

WHR

796

1.53

1.0 × 10−6

1.49

4.4 × 10−4

1.12

0.78

1.52

3.1 × 10−6

1.56

4.5 × 10−50

1.60

5.9 × 10−47

1.23

0.21

1.57

3.6 × 10−50

T2D

561

1.05

0.08

1.07

0.08

0.86

0.29

1.06

0.06

1.16

1.1 × 10−41

1.18

1.4 × 10−45

1.16

4.3 × 10−4

1.16

3.3 × 10−39

HDL

362

1.04

0.44

0.92

0.35

1.23

0.21

1.06

0.27

0.87

6.1 × 10−9

0.87

1.5 × 10−8

0.89

0.17

0.88

9.6 × 10−11

LDL

301

1.04

0.43

0.98

0.78

0.86

0.29

1.02

0.67

1.31

7.2 × 10−35

1.19

2.3 × 10−13

1.11

0.19

1.44

3.4 × 10−211

TC

308

1.12

0.03

1.03

0.63

0.97

0.85

1.12

0.04

1.38

7.4 × 10−41

1.22

3.9 × 10−16

1.43

8.6 × 10−4

1.48

1.4 × 10−222

TG

353

1.07

0.16

1.01

0.87

0.84

0.34

1.06

0.22

1.21

3.6 × 10−20

1.16

2.7 × 10−10

1.15

0.02

1.21

5.8 × 10−24

  1. Results significant after Bonferroni adjustment are indicated in bold.
  2. IVW inverse-variance weighted, Num. number of, CAD coronary artery disease, BMI body mass index, WHR waist-hip ratio, T2D type 2 diabetes, HDL high-density lipoprotein, LDL low-density lipoprotein, TC total cholesterol, TG triglycerides, OR odds ratio, p p-value.
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