Fig. 3: FAAH activity can be detected in mouse lung.
From: The endocannabinoid anandamide is an airway relaxant in health and disease
a Analysis of FAAH expression in different generations of C57BL/6J mouse airways (trachea, 1st, 2nd, 3rd airway generation n = 3), lung (n = 4), heart (n = 4), and brain (n = 4) demonstrates high FAAH levels. Organs were derived from independent animals. b, c FAAH activity can be found in C57BL/6J mouse trachea, original graph (b), statistical analysis (c) (n = 3 independent animals), unpaired two-tailed Student’s t test ***p = 7.0 × 10−4. d, e FAAH activity can be also found in C57BL/6J mouse lung tissue, original graph (d), statistical analysis (e) (n = 3 independent animals), unpaired two-tailed Student’s t test **p = 0.0023). f, g Analysis demonstrates high FAAH activity in mouse brain (positive control, f) but not in mouse heart (negative control, g) (n = 3 independent animals), unpaired two-tailed Student’s t test ***p = 3.3 × 10−6 (f). h, i In human cells FAAH activity can be detected in hTEPC (h) but not in hASMC (i) (n = 5 independent samples), unpaired two-tailed Student’s t test **p = 0.0013 (h); URB597 (URB, 10 µM). All data are presented as mean values ± SEM, 7-amino-4-methylcoumarin (AMC). Source data are provided as a Source Data file.
