Fig. 5: Endocannabinoids as well as expression levels of enzymes promoting AEA synthesis are reduced in lungs of OVA-sensitized mice. | Nature Communications

Fig. 5: Endocannabinoids as well as expression levels of enzymes promoting AEA synthesis are reduced in lungs of OVA-sensitized mice.

From: The endocannabinoid anandamide is an airway relaxant in health and disease

Fig. 5

a–e Tissue levels of AEA (a), 2-Arachidonylglycerol (2-AG, b), AA (c), oleoylethanolamine (OEA, d), and palmitoylethanolamine (PEA, e) are reduced in OVA lungs of Balb/c mice (n = 10 independent animals). Unpaired two-tailed Student’s t test (AEA *p = 0.026; 2-AG **p = 0.0034; AA **p = 0.003; OEA **p = 0.005; PEA *p = 0.032). f–i Expression of N-acyl-phosphatidyl-ethanolamine phospholipase D (NAPE-PLD, f), a/b-hydrolase domain-containing protein (ABDH4, g), glycerophosphodiesterase 1 (GDE1, h) but not protein tyrosine phosphatase nonreceptor type 22 (PTPN22, i) is diminished in OVA-sensitized Balb/c mice (n = 5 independent animals), unpaired two-tailed Student’s t test (NAPE *p = 0.010; ABDH4 *p = 0.013; GDE *p = 0.037). All data are presented as mean values ± SEM. Source data are provided as a Source Data file.

Back to article page