Fig. 2: Synthesis and characterization of functional polymers. | Nature Communications

Fig. 2: Synthesis and characterization of functional polymers.

From: Ligand-switchable nanoparticles resembling viral surface for sequential drug delivery and improved oral insulin therapy

Fig. 2: Synthesis and characterization of functional polymers.

a Schematic illustration of pH-responsive stretchable cell-penetrating peptide (Pep) and polyethylene glycol-galactose (PEG-Gal) polymers and their theoretical lengths. Open- and closed-state models of Pep under different pH conditions. H: histidine; E: glutamic acid; G: glycine; R: arginine. b Mass spectrum of Pep. c Circular dichroism spectra of Pep under different pH conditions. d Emission spectra of FRET pair-labeled Pep under different pH conditions. e The synthetic route to PLGA-Pep polymers. f 1H NMR spectra of PLGA-Mal and PLGA-Pep polymers. Characteristic peaks are assigned according to the labels in panel (e). g The synthetic route to PLGA-PEG-Gal polymers. h 1H NMR spectra of PLGA-COOH and PLGA-PEG-Gal polymers. Characteristic peaks are assigned according to the labels in panel (g).

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