Fig. 4: Electrostatic assistance of the NCL reaction. | Nature Communications

Fig. 4: Electrostatic assistance of the NCL reaction.

From: A biomimetic electrostatic assistance for guiding and promoting N-terminal protein chemical modification

Fig. 4

a Principle of the NCL reaction. b, c Assistance of the NCL reaction enables peptide formation in the low micromolar range with rates up to 31000 M−1 s−1. The errors for rate constants correspond to the standard error generated by Kintek Global Kinetic Explorer Software during the numerical fitting of the data (95% confidence interval). d, e Application of electrostatic assistance to the modification of K1 HGF domain at 1 µM.

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