Table 3 Treatment-emergent adverse events occurring in 5% or more of patients (N = 36)
No. (%) | |||||
|---|---|---|---|---|---|
Any grade | Grade 1 | Grade 2 | Grade 3 | Grade 4 | |
Any events | 36 (100) | 36 (100) | 28 (77.8) | 25 (69.4) | 6 (16.7) |
General disorders | |||||
Weight loss | 5 (13.9) | 2 (5.6) | 3 (8.3) | 0 | 0 |
Cough | 2 (5.6) | 2 (5.6) | 0 | 0 | 0 |
Urinary tract infection | 2 (5.6) | 1 (2.8) | 1 (2.8) | 0 | 0 |
Hematological | |||||
Lymphocyte count decreased | 35 (97.2) | 3 (8.3) | 5 (13.9) | 24 (66.7) | 3 (8.3) |
White blood cell decreased | 26 (72.2) | 9 (25.0) | 15 (41.7) | 2 (5.6) | 0 |
Anemia | 25 (69.4) | 21 (58.3) | 4 (11.1) | 0 | 0 |
Platelet count decreased | 19 (52.8) | 13 (36.1) | 6 (16.7) | 0 | 0 |
Neutropenia | 17 (47.2) | 9 (25.0) | 8 (22.2) | 0 | 0 |
Biochemistry | |||||
Hypocalcaemia | 6 (16.7) | 5 (13.9) | 1 (2.8) | 0 | 0 |
Hypokalemia | 3 (8.3) | 3 (8.3) | 0 | 0 | 0 |
Hyponatremia | 3 (8.3) | 2 (5.6) | 1 (2.8) | 0 | 0 |
Hypoalbuminemia | 3 (8.3) | 2 (5.6) | 1 (2.8) | 0 | 0 |
Hyperuricemia | 3 (8.3) | 3 (8.3) | 0 | 0 | 0 |
Blood bilirubin increased | 2 (5.6) | 1 (2.8) | 1 (2.8) | 0 | 0 |
Gastrointestinal disorders | |||||
Vomiting | 16 (44.4) | 11 (30.6) | 5 (13.9) | 0 | 0 |
Nausea | 15 (41.7) | 12 (33.3) | 2 (5.6) | 1 (2.8) | 0 |
Loss of appetite | 3 (8.3) | 2 (5.6) | 1 (2.8) | 0 | 0 |
Diarrhea | 2 (5.6) | 2 (5.6) | 0 | 0 | 0 |
Abdominal distension | 2 (5.6) | 2 (5.6) | 0 | 0 | 0 |
Constipation | 2 (5.6) | 2 (5.6) | 0 | 0 | 0 |
