Fig. 4: Comparison of temporal patterns of common lipids for patients with trauma or COVID-19. | Nature Communications

Fig. 4: Comparison of temporal patterns of common lipids for patients with trauma or COVID-19.

From: Lipidomic signatures align with inflammatory patterns and outcomes in critical illness

Fig. 4: Comparison of temporal patterns of common lipids for patients with trauma or COVID-19.The alt text for this image may have been generated using AI.

a, d Heatmaps show the relative levels of 29 common lipid species from four major classes across patients. Data comes from trauma patients from the PAMPer lipidomics dataset (a) and TD-2 untargeted metabolomics dataset (b); COVID-19 patients from untargeted metabolomics dataset (Guo et al. Cell, 2020) (c) and lipidomics dataset (Shui et al., Cell metabolism, 2020) (d). Patients are grouped by outcome and sampling timepoint (except for d). Asterisks indicate lipids with statistical significance (p value <0.05) and log2 fold change >0.4 by two-sided Wilcoxon Rank Sum test between non-resolving and resolving trauma patients at 72 h (a); non-resolving and resolving trauma patients at D2-D5 (b); severe and non-severe Covid-19 patients (c); severe and mild Covid-19 patients (d). Abbreviations: PE phosphatidylethanolamines, PC phosphatidylcholines, PI phosphatidylinositols, SM sphingomyelins.

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