Fig. 2: Results of the Exposome-omics-Wide Association Study (ExWAS) for the pregnancy and childhood exposomes.

A Summary of the associations between the pregnancy exposome and multi-omics measured in 1301 children: Miami plot (1); pie charts showing the proportion of associations with the different molecular layers (2); and top 10 pregnancy exposures (3). B Summary of the childhood exposome-child omics associations: Miami plot (1); pie charts showing the proportion of associations with the different molecular layers (2); and top 10 childhood exposures (3). In Miami plots, each point corresponds to an exposure-omics association; the y-axes show the −log10 p values multiplied by the direction of the association (sign of the regression coefficient); and the x-axis groups exposures along the 19 exposure families and each vertical line represents a separate exposure with some jitter added to avoid overlapping points. In the Manhattan (dots), pie-chart and histogram, colours indicate the molecular layer.