Fig. 1: Impact of CD28 costimulation blockade on Treg homeostasis. | Nature Communications

Fig. 1: Impact of CD28 costimulation blockade on Treg homeostasis.

From: Costimulation blockade in combination with IL-2 permits regulatory T cell sparing immunomodulation that inhibits autoimmunity

Fig. 1: Impact of CD28 costimulation blockade on Treg homeostasis.The alternative text for this image may have been generated using AI.

6–9 week old BALB/c mice were injected i.p. with anti-CD80/86 Ab or control Ab on d0 and d6. At d8, spleen (Spl) and peripheral lymph node (LN) cells were harvested for analysis. a Representative FACS plots show Treg percentage in gated CD4 + cells from either spleen or peripheral lymph nodes b. Collated data for Treg percentage (left) and Treg absolute number (right) (n = 7 per group). Representative FACS plots from spleen c and pooled data d illustrate Ki67 expression on Treg (CD4 + Foxp3+) or Tconv (CD4 + Foxp3-) (n = 7 per group). Data are collated from 3 independent experiments. Graphs b and d show mean±s.d.; each dot represents one mouse. **P < 0.01, ***P < 0.001, ****P < 0.0001 (two-tailed t test). Source data are provided as a Source Data file.

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