Fig. 2: Serum profiling of vaccine responders and non-responders reveals differentially regulated factors. | Nature Communications

Fig. 2: Serum profiling of vaccine responders and non-responders reveals differentially regulated factors.

From: Distinct immunological and molecular signatures underpinning influenza vaccine responsiveness in the elderly

Fig. 2: Serum profiling of vaccine responders and non-responders reveals differentially regulated factors.The alternative text for this image may have been generated using AI.

Cryopreserved serum samples derived from the triple responders and non-responders at all analyzed time points were subjected to a bead-based flow cytometric measurement based on Luminex technology. A Heat map showing the ratio of cytokine concentrations detected before vaccination in responders vs. non-responders. B Heat map depicting the ratio of vaccine-induced serum factors (fold increase over day 0) for triple vaccine responders as compared to non-responders. Orange represents values that show a higher response in responders as compared to non-responders, blue indicates a higher response in non-responders, 2nd study, n = 10 responders, n = 10 non-responders, biologically independent samples). Source data are provided as a Source Data file.

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