Table 2 Microbiota significantly associated with depressive symptoms
From: Gut microbiome-wide association study of depressive symptoms
Taxon | Rotterdam Study (N = 1054) | HELIUS (N = 1539) | Meta-analysis | |||||||
|---|---|---|---|---|---|---|---|---|---|---|
Beta | Se | p | fdr | Beta | Se | P-value | N | Zscore | P-value | |
family.Christensenellaceae.id.1866 | −0.59 | 0.12 | 4.56E–07 | 8.04E–05 | −0.10 | 0.06 | 1.32E–01 | 2593 | −1.88 | 5.96E–02 |
genus.ChristensenellaceaeR7group.id.11283 | −0.55 | 0.11 | 3.31E–07 | 8.04E–05 | −0.10 | 0.06 | 1.30E–01 | 2593 | −4.42 | 9.80E–06 |
genus.RuminococcaceaeUCG005.id.11363 | −0.59 | 0.13 | 1.36E–05 | 1.57E–03 | −0.12 | 0.07 | 7.62E–02 | 2593 | −4.14 | 3.48E–05 |
genus.RuminococcaceaeUCG010.id.11367 | −0.50 | 0.12 | 1.77E–05 | 1.57E–03 | −0.07 | 0.06 | 2.08E–01 | 2593 | −3.71 | 2.11E–04 |
family.Ruminococcaceae.id.2050 | −1.59 | 0.38 | 2.51E–05 | 1.77E–03 | −0.52 | 0.24 | 3.11E–02 | 2593 | −4.35 | 1.38E–05 |
genus.Coprococcus2.id.11302 | −0.29 | 0.08 | 2.74E–04 | 1.03E–02 | −0.02 | 0.04 | 5.79E–01 | 2593 | −2.75 | 6.02E–03 |
genus.FamilyXIIIAD3011group.id.11293 | −0.74 | 0.20 | 2.56E–04 | 1.03E–02 | −0.06 | 0.10 | 5.78E–01 | 2593 | −2.76 | 5.78E–03 |
genus.Lachnoclostridium.id.11308 | 0.57 | 0.16 | 3.11E–04 | 1.03E–02 | 0.27 | 0.11 | 1.80E–02 | 2593 | 4.12 | 3.76E–05 |
genus.RuminococcaceaeUCG002.id.11360 | −0.42 | 0.12 | 3.21E–04 | 1.03E–02 | −0.16 | 0.07 | 2.33E–02 | 2593 | −4.04 | 5.30E–05 |
genus.RuminococcaceaeUCG003.id.11361 | −0.51 | 0.15 | 4.60E–04 | 1.33E–02 | −0.25 | 0.08 | 3.10E–03 | 2593 | −4.51 | 6.42E–06 |
class.Mollicutes.id.3920 | −0.39 | 0.12 | 8.63E–04 | 1.38E–02 | −0.01 | 0.05 | 8.04E–01 | 2593 | −2.32 | 2.06E–02 |
genus.Eggerthella.id.819 | 0.65 | 0.19 | 6.28E–04 | 1.38E–02 | 0.31 | 0.12 | 1.18E–02 | 2593 | 4.12 | 3.80E–05 |
genus.Hungatella.id.11306 | 0.77 | 0.22 | 6.73E–04 | 1.38E–02 | 0.34 | 0.14 | 1.34E–02 | 2593 | 4.07 | 4.65E–05 |
genus.Ruminiclostridium6.id.11356 | −0.36 | 0.11 | 6.23E–04 | 1.38E–02 | −0.01 | 0.05 | 9.06E–01 | 2593 | −2.27 | 2.31E–02 |
genus.RuminococcaceaeUCG014.id.11371 | −0.29 | 0.08 | 5.70E–04 | 1.38E–02 | −0.05 | 0.05 | 3.16E–01 | 2593 | −2.97 | 2.99E–03 |
order.MollicutesRF9.id.11579 | −0.40 | 0.12 | 8.28E–04 | 1.38E–02 | 0.00 | 0.05 | 9.55E–01 | 2593 | −2.18 | 2.96E–02 |
phylum.Tenericutes.id.3919 | −0.39 | 0.12 | 8.63E–04 | 1.38E–02 | −0.01 | 0.05 | 8.04E–01 | 2593 | −2.32 | 2.06E–02 |
genus.Coprococcus3.id.11303 | −0.43 | 0.13 | 9.09E–04 | 1.39E–02 | −0.29 | 0.09 | 1.20E–03 | 2593 | −4.61 | 4.04E–06 |
genus.LachnospiraceaeUCG001.id.11321 | −0.52 | 0.16 | 1.01E–03 | 1.48E–02 | −0.16 | 0.07 | 2.34E–02 | 2593 | −3.84 | 1.21E–04 |
family.Micrococcaceae.id.636 | 1.53 | 0.47 | 1.26E–03 | 1.71E–02 | −0.14 | 0.16 | 3.75E–01 | 2593 | 2.92 | 3.55E–03 |
genus..Ruminococcusgauvreauiigroup.id.11342 | −0.34 | 0.11 | 1.54E–03 | 2.01E–02 | −0.13 | 0.07 | 4.90E–02 | 2593 | −3.54 | 4.06E–04 |
genus..Eubacteriumventriosumgroup.id.11341 | −0.49 | 0.16 | 2.09E–03 | 2.47E–02 | −0.17 | 0.08 | 4.20E–02 | 2593 | −3.53 | 4.19E–04 |
genus.Sellimonas.id.14369 | 0.57 | 0.18 | 2.10E–03 | 2.47E–02 | 0.54 | 0.13 | 3.55E–05 | 2593 | 5.15 | 2.65E–07 |
genus.Rothia.id.646 | 1.47 | 0.48 | 2.21E–03 | 2.52E–02 | 0.32 | 0.23 | 1.66E–01 | 2593 | 3.02 | 2.55E–03 |
order.Micrococcales.id.510 | 1.41 | 0.47 | 2.58E–03 | 2.84E–02 | −0.21 | 0.15 | 1.68E–01 | 2593 | 2.96 | 3.09E–03 |
genus.LachnospiraceaeNK4A136group.id.11319 | −0.41 | 0.14 | 2.80E–03 | 2.99E–02 | −0.08 | 0.08 | 3.48E–01 | 2593 | −2.63 | 8.56E–03 |
genus.Subdoligranulum.id.2070 | −0.44 | 0.15 | 3.36E–03 | 3.48E–02 | −0.28 | 0.09 | 1.66E–03 | 2593 | −4.29 | 1.77E–05 |
genus.RuminococcaceaeNK4A214group.id.11358 | −0.34 | 0.12 | 4.66E–03 | 4.70E–02 | −0.04 | 0.06 | 5.73E–01 | 2593 | −2.24 | 2.52E–02 |
genus.PrevotellaceaeUCG001.id.11186 | −0.49 | 0.17 | 4.80E–03 | 4.71E–02 | −0.02 | 0.08 | 8.38E–01 | 2593 | −1.96 | 5.06E–02 |
