Fig. 2: Cryo-EM structure of the double mutant Drg1E346Q/E617Q hexamer in the presence of ATP. | Nature Communications

Fig. 2: Cryo-EM structure of the double mutant Drg1E346Q/E617Q hexamer in the presence of ATP.

From: Structural dynamics of AAA + ATPase Drg1 and mechanism of benzo-diazaborine inhibition

Fig. 2

a, b Cryo-EM map of the double mutant Drg1E346Q/E617Q hexamer in the presence of ATP, viewed from the D2 (a) and NTD (b) directions. c Side view of the double mutant Drg1E346Q/E617Q hexamer, highlighting its helical configuration of protomers. d Cross-section view shows the trapped substrate within the central channel of the double mutant Drg1E346Q/E617Q hexamer.

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