Fig. 8: Structural comparison of the NTD-D1 and D1-D2 linker in the Drg1 hexamers.
From: Structural dynamics of AAA + ATPase Drg1 and mechanism of benzo-diazaborine inhibition
a, b Structural comparison of the NTD-D1 linker in the structures of p97 (a) and Drg1 (b). c Interaction details of the NTD-D1 linker in the structure of Drg1 hexamer. d–f Structure of the D1-D2 linker in the substrate-engaged (translocating) Drg1 hexamer. Detailed interactions are shown in e, f. The D1-D2 linker is shown in purple. g–i Structure of the D1-D2 linker in the benzo-diazaborine bounded (non-translocating) hexamers. Detailed interactions are shown in h–i.
