Fig. 1: Cross-reactivity of the three mAbs. | Nature Communications

Fig. 1: Cross-reactivity of the three mAbs.

From: A broadly protective human monoclonal antibody targeting the sialidase activity of influenza A and B virus neuraminidases

Fig. 1

Heat maps of antibody binding to NA-displaying VLPs in ELISA, NI activity in ELLA, and neutralization potencies in an MN assay are shown in blue, red, and green, respectively. NAs are derived from A circulating human influenza subtypes or highly pathogenic viruses (A/H5N1 or A/H7N9) or B recent A/H3N2 human isolates or animal influenza viruses. The exact minimal binding concentration, 50% inhibition concentration for sialidase activity (IC50), and 50% neutralization concentration are listed in Tables S2–S4. Source data are provided as a Source Data file.

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