Fig. 3: Positions and conservation of key residues for escape from DA03E17. | Nature Communications

Fig. 3: Positions and conservation of key residues for escape from DA03E17.

From: A broadly protective human monoclonal antibody targeting the sialidase activity of influenza A and B virus neuraminidases

Fig. 3

A Amino acid positions that are important for escape from DA03E17 are shown on the NA structure of A/Minnesota/11/2010 (A/H3N2; PDB accession code 6N6B) virus. Each NA monomer is indicated in white, gray, or black. Cyan indicates catalytic residues; magenta and red indicate amino acids that are essential for escape from DA03E17. B Amino acid alignment of NAs from viruses was used in this study. Amino acids with electrically positive-charged side chains, negative-charged side chains, polar side chains, or nonpolar side chains are indicated in cyan, orange, green, or black, respectively. Key residues for escape are indicated in dotted boxes in magenta and red. Source data are provided as a Source Data file.

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