Table 3 Neutralization activity against mutant viruses possessing amino acid substitutions in NA
mAb | IC50 value (μg/ml) against variant viruses possessing amino acid substitutions of escape mutants | ||||||
|---|---|---|---|---|---|---|---|
Wild-type | D151G | D151N + T439A | V50L + D151G | D151N | T439A | V50L | |
DA03E17 | 15.8 | >50 | >50 | >50 | >50 | 39.7 | 17.7 |
1G01 | 3.13 | 15.8 | 9.92 | 8.84 | 9.92 | 4.42 | 6.25 |
CR9114 | 3.13 | 6.25 | 4.96 | 4.96 | 1.56 | 4.42 | 6.25 |
1430E3/9 | >50 | >50 | >50 | >50 | >50 | >50 | >50 |
