Fig. 3: Differential cell composition and gene expression in CSF of ALS patients versus controls.
From: T cell responses at diagnosis of amyotrophic lateral sclerosis predict disease progression
t-SNE plots of 10X scRNA-seq data showing leukocyte subsets from five ALS patients and four controls (A). A pairwise comparison of ALS and controls in terms of cell count abundance for every cell type was performed using a two-sided proportions z-test (horizontal dotted lines correspond to P = 0.05) which was followed by Yate’s continuity correction. Correction for multiple testing was done using Benjamini–Hochberg (BH) correction (B). Heat map illustrating the top-up to five most up- and down-regulated genes in different T cell subsets in ALS patients (N = 5) versus controls (N = 4) (C).
