Table 3 B-factors for residues in the CTX-M-14 and CTX-M-15 β-lactamase 103-106 loop

From: An active site loop toggles between conformations to control antibiotic hydrolysis and inhibition potency for CTX-M β-lactamase drug-resistance enzymes

 

B-factor (Å2)

 

Residue position

main chain

side chain

all

normalized B-factora

Val103 CTX-M-14

6.23

7.42

6.74

−0.697

Val103 CTX-M-15

8.34

9.27

8.74

−0.200

Asn104 CTX-M-14

7.65

10.80

9.22

-0.082

Asn104 CTX-M-15

8.23

16.64

12.44

0.304

Tyr105 CTX-M-14

6.31

10.16

8.87

−0.169

Tyr105 CTX-M-15

9.79

25.68

20.38

1.386

Asn106 CTX-M-14

6.83

7.27

7.05

−0.620

Asn106 CTX-M-15

8.78

16.18

12.48

0.309

  1. aNormalized B factor calculated as (B - < B > )/σ, where <B > is the average B-factor for the main chain and side chains for the structure and σ is the standard deviation (SD). Average B-factor and SD for all (main chain and side chain) for the CTX-M-15 structure is 10.21 and 7.34, respectively. The avg B-factor and SD for CTX-M-14 is 9.55 and 4.03, respectively. The B-factors are calculated for CTX-M-15 PDB id:4HBT and CTX-M-14 PDB id:1YLT.
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