Fig. 1: Cryo-EM structure of full-length TLR3 in complex with poly(I:C) RNA.
From: TLR3 forms a highly organized cluster when bound to a poly(I:C) RNA ligand
a Representative micrographic image of the TLR3-poly(I:C) complex. TLR3 forms regularly spaced and linear clusters along the poly(I:C) RNA strands. b Representative 2D class average of the TLR3-poly(I:C) complex. c Electron density map of the TLR3-poly(I:C) complex. Atomic models of two neighboring TLR3 dimers are superimposed. The transmembrane and intracellular domains are not visible in the map, presumably due to structure flexibility at the juxtamembrane regions. A representative micrograph from an n = 9527 cryo-EM experiment set is shown.
