Fig. 3: Effect of TLR3 concentration on cluster formation.
From: TLR3 forms a highly organized cluster when bound to a poly(I:C) RNA ligand
a–c Representative micrograph images of the ectoTLR3-poly(I:C) complex with different ratios of TLR3 vs. available binding sites in the poly(I:C). The TLR3s in the clustered (middle) and dimeric states (right) and are marked with green circles. Representative micrographs are from n = 1087 (a), n = 1029 (b) and n = 1081 (c) cryo-EM experiment sets, respectively. d The histogram shows the ratio of TLR3 particles in the clustered state vs. the dimeric state by varying the ratio of TLR3 molecules and the TLR3 binding sites available in poly(I:C). Source data are provided as a Source Data file.
