Fig. 6: Impaired spatial learning in the Barnes maze test in PKCα M489V mice + AD transgenic mouse. | Nature Communications

Fig. 6: Impaired spatial learning in the Barnes maze test in PKCα M489V mice + AD transgenic mouse.

From: Enhanced activity of Alzheimer disease-associated variant of protein kinase Cα drives cognitive decline in a mouse model

Fig. 6

Percent time in the target quadrant (filled bars) vs. the average of the other quadrants (clear bars) in the probe test in separate groups of 4.5 (a), 6 (b) and 12 (c) month-old mice. Group sizes: 4.5-month (WT non tg-AD (WT): 12 males, 12 females, M489V non tg-AD (M489V): 11 males, 12 females, WT harboring the APPswe transgene (WT tg-AD): 11 males, 11 females, M489V harboring the APPswe transgene (M489V tg-AD): 12 males, 12 females), 6-month (WT: 15 males, 16 females, M489V: 12 males, 16 females, WTAPP: 10 males, 11 females, M489VAPP: 8 males, 6 females), 12 month (WT: 10 males, 10 females, M489V: 10 males, 9 females, WTAPP: 9 males, 9 females, M489VAPP: 5 males, 14 females). Error bars show standard error of the mean. No statistically significant sex differences were found. ANOVA was used for statistical analysis, followed by post hoc two-tailed Student’s t test to determine the p values. Source data are provided in the Source Data file.

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