Fig. 5: MYC amplification with HR proficiency was associated with OXPHOS activation and poor prognosis. | Nature Communications

Fig. 5: MYC amplification with HR proficiency was associated with OXPHOS activation and poor prognosis.

From: Multi-omics analysis identifies osteosarcoma subtypes with distinct prognosis indicating stratified treatment

Fig. 5

A Comparison of the tumor necrosis rate among integrative subtypes. The statistical analysis was made by ANOVA with Tukey’s multiple comparisons test. (P < 0.0001). B Gene expression level of MYC in each subtype. The Student’s t test was adopted in significant difference analysis between S-HRD and S-MD. C Rearrangements of MYC tested by FISH and expression level of MYC protein measured with IHC. 3 times repeated independently. D GSEA between MYC-amplified and MYC unamplified OS. E, F GSEA between MYC-amplified HR proficiency and MYC-amplified HR deficiency OS.

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