Fig. 2: Scanning electron microscopic images of lung tissue of T. b. brucei infected mice.
From: Impact of pulmonary African trypanosomes on the immunology and function of the lung
Groups of three C57BL/6JRj mice were infected via the bite of a T. b. brucei AnTar1 infected G. morsitans tsetse fly. After perfusion of the vascular system at 10 dpi, lungs were fixed in glutaraldehyde and embedded in 1% agarose prior to vibratome sectioning. a–f Extravascular parasites embedded in lung tissue. g–h Examples of extracellular vesicles as “beads on a string”. Cb collagen bundle, Rf reticular fibre, WBC white blood cell, E endothelium, EV extracellular vesicles, FP flagellar pocket, arrows: T. b. brucei parasites, arrowheads: multiplying parasites, double arrowhead: cell–cell communication via string of extracellular vesicles. EVs size evaluation in h, 137.98 +/− 23.21 nm (185.64 − 89.93 nm), n = 26, not-corrected for depth.
