Fig. 3: Activation of DNMT1 by a pair of phenylalanine residues in the Activating Helix. | Nature Communications

Fig. 3: Activation of DNMT1 by a pair of phenylalanine residues in the Activating Helix.

From: Structural basis for activation of DNMT1

Fig. 3

a Domain structure of DNMT1. b Structure around Activating Helix (green), DNA Recognition Helix (pink), and Toggle Pocket (pale cyan) of apo-DNMT1 (PDB:4WXX). The Toggle Pocket is highlighted by a light blue circle. The right panel is a magnified figure of the Toggle Pocket. Residues in Activating Helix and DNA Recognition Helix that are involved in binding to the Toggle Pocket are shown as green and pink stick models, respectively. Residues for the formation of the Toggle Pocket are shown as a stick with a transparent sphere model. c Structure around Activating Helix (green), DNA Recognition Helix (pink), and Toggle Pocket (pale cyan) of the ternary complex. The color scheme is the same as Fig. 3b. d Multiple sequence alignment of DNMT1 around the Activating Helix. Phenylalanines 628, 631, and 632 are highlighted.

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