Fig. 1: Asymmetric synthesis of enantioenriched olefins featuring allylic (trifluoro)methyl stereocenters. | Nature Communications

Fig. 1: Asymmetric synthesis of enantioenriched olefins featuring allylic (trifluoro)methyl stereocenters.

From: Asymmetric construction of allylicstereogenic carbon center featuring atrifluoromethyl group via enantioselective reductive fluoroalkylation

Fig. 1

a Stereochemically complex biologically important molecules bearing allylic methyl stereocenters. b Strategies for accessing enantioenriched olefins bearing allylic methyl stereocenters. c Known strategies for synthesis of chiral olefins featuring allylic trifluoromethyl stereogenic carbon centers. d Our strategy to enantioenriched a-trifluoromethyl olefins. e This work: Nickel-catalyzed asymmetric reductive coupling to construct allylic trifluoromethyl stereocenters.

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