Fig. 2: Nickel-catalyzed asymmetric reductive trifluoroalkylation of vinyl iodides. | Nature Communications

Fig. 2: Nickel-catalyzed asymmetric reductive trifluoroalkylation of vinyl iodides.

From: Asymmetric construction of allylicstereogenic carbon center featuring atrifluoromethyl group via enantioselective reductive fluoroalkylation

Fig. 2

Reaction conditions: 1 (0.10 mmol, 1.0 equiv), 2 (0.20 mmol, 2.0 equiv), NiBr2•DME (10 mol%), L9 (13 mol%), Mn (0.20 mmol, 2.0 equiv), TBAI (0.10 mmol, 1.0 equiv), THF (0.45 mL), N,N-Dimethylpropionamide (0.05 mL), −4 °C, 20 h; all reported yields are isolated yields; the ee values were determined by HPLC on a chiral stationary phase.

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