Fig. 2: Pear1 deficiency expanded activated fibroblasts in bleo model. | Nature Communications

Fig. 2: Pear1 deficiency expanded activated fibroblasts in bleo model.

From: PEAR1 regulates expansion of activated fibroblasts and deposition of extracellular matrix in pulmonary fibrosis

Fig. 2

a–c All of the 17,934 mesenchymal cells across four experiment conditions were integrated for umap clustering (a), cell type annotation and cluster-tree dendrogram (b), and fraction of each cell type in each experimental condition (c). d GSEA analysis of activated fibroblasts signature of cluster 7 compared with the rest clusters. e Dotplot of markers for the selected cluster. f, g Top 10 GO biological process (f) and KEGG pathways (g) enriched with Cluster 7 markers in Pear1−/− bleo mice. h Differentially expressed genes in Cluster 7 between Pear1−/− bleo and WT bleo. For d, nominal P value for the statistical significance of the enrichment score is adjusted using Benjamini–Hochberg method for multiple gene sets and hypothesis testing. For f, g, one-sided Fisher’s exact test was used.

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