Fig. 2: Structure of the human EXT1-EXT2 complex.
From: Structure of the human heparan sulfate polymerase complex EXT1-EXT2
a EM map of the hetero-dimeric EXT1-EXT2 complex, with density covering EXT1 in orange and EXT2 in blue. Both proteins harbor a glucuronic acid transferase (GlcA-T) domain and a N-acetylglucosamine transferase (GlcNAc-T) domain colored in darker and lighter shades, respectively. Densities of N-glycans are colored in yellow. The N-terminal membrane anchoring helices, absent in our expression constructs, are drawn as cylinders. b Cartoon representation of the complex with coloring as in a and glycosylations shown in stick representation. Missing loops are indicated as dotted lines. c Rotated view showing the GlcA-T domains from the membrane plane.
