Fig. 1: Plasma IFNα is consistently reduced with increasing severity of Covid-19. | Nature Communications

Fig. 1: Plasma IFNα is consistently reduced with increasing severity of Covid-19.

From: Defective activation and regulation of type I interferon immunity is associated with increasing COVID-19 severity

Fig. 1

a IFNα2 (left) and b multi-IFNα subtypes (=equivalent IFNα17) were measured by Simoa digital ELISA or c Luminex in healthy controls (n = 14 donors) and in patients with moderate (n = 15), severe (n = 13) and critical (n = 27) disease from the first Hopital Cochin cohort. Interferon-stimulated gene (ISG) score (6 gene score) correlated with IFNα levels measured by d Simoa IFNα2, e Simoa multi IFNα subtypes or f Luminex; n = 64. IFN activity (IU/mL) correlated with IFNα levels measured by g Simoa IFNα2, h Simoa multi IFNα subtypes, or i Luminex IFNα2; n = 35. j IFNα2, k multi-IFNα subtypes (=equivalent IFNα17) were measured by Simoa digital Elisa or l IFNα2 by Luminex in patients with moderate (n = 35), severe (n = 32) and critical (n = 21) disease from the second Hopital Cochin cohort. Lines indicate median values. P values were determined by multimodal regression models incorporating age and sex. Rs represents the Spearman coefficient. Healthy control = black, moderate COVID-19 patients = blue, severe COVID-19 patients = purple and critical COVID-19 patients = red. N = number of individual patients included. Source data are provided as a Source Data file.

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