Fig. 2: Plasma IFNα is consistently reduced in hospitalized patients independent of neutralizing auto-antibodies. | Nature Communications

Fig. 2: Plasma IFNα is consistently reduced in hospitalized patients independent of neutralizing auto-antibodies.

From: Defective activation and regulation of type I interferon immunity is associated with increasing COVID-19 severity

Fig. 2

a IFNα2 and b multi-IFNα subtypes (=equivalent IFNα17) measured by digital ELISA Simoa in healthy controls (n = 14 donors), non-hospitalized (n = 51), or hospitalized (n = 85) COVID-19 patients of the St. James Hospital cohort. c Anti-IFNα and d anti-IFNω auto-antibodies in plasma of these healthy controls and COVID-19 patients. e IFNα2 and f multi-IFNα subtype cytokine levels as a function of the number of days post symptoms, with regression lines per COVID-19 patient groups shown. P values were determined by multimodal regression models incorporating age and sex. Lines indicate the median values. Healthy control = black, non-hospitalized COVID-19 patients = green, and hospitalized COVID-19 patients = orange. Rs indicates Spearman correlation, n = number of individual patients included. Source data are provided as a Source Data file.

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