Fig. 6: Downstream signaling response to IFNα is perturbed in hospitalized patients. | Nature Communications

Fig. 6: Downstream signaling response to IFNα is perturbed in hospitalized patients.

From: Defective activation and regulation of type I interferon immunity is associated with increasing COVID-19 severity

Fig. 6

a Type I interferon gene signature (ISG) score calculated from Nanostring data in healthy controls (black, n = 19), moderate COVID-19 patients (green, n = 28), and hospitalized COVID-19 patients (orange, n = 18) in the Null control, and after stimulation with IFNα, Poly:IC, and R848. b Heat map of all IFN stimulated genes identified from Nanostring data in healthy controls (black), moderate COVID-19 patients (green), and hospitalized COVID-19 patients (orange). Pathways identified to be enriched after IFNα stimulation in c healthy donors and f hospitalized COVID-19 patients. Nanostring gene expression of d MX1, e TLR3 and TLR7, and g IL1R1 in whole blood of healthy controls (black), moderate COVID-19 patients (green), and hospitalized COVID-19 patients (orange). Black lines represent the medians. P values were determined with the Kruskal–Wallis test followed by Dunn’s post hoc test for multiple comparisons. N = number of individual patients included. Source data are provided as a Source Data file.

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