Fig. 2: The scope of alkyl bromides. | Nature Communications

Fig. 2: The scope of alkyl bromides.

From: Regioselective Ni-Catalyzed reductive alkylsilylation of acrylonitrile with unactivated alkyl bromides and chlorosilanes

Fig. 2

Reaction conditions: 1 (0.4 mmol), 2a (0.6 mmol), 3a (1.2 mmol), Ni(PPh3)2Cl2 (10 mol%), L4 (20 mol%), Zn (1.2 mmol), DMA (2 mL), 35 °C, 36 h, N2 atmosphere. Isolated yield was shown. b2a (1.2 mmol) and 3a (2.4 mmol) were used, as well as 24% of mono-alkylsilylation obtained. cThe reaction run at 50 °C for 48 h. dIodocyclopentane as the substrate. d.r. diastereomeric ratio. Boc tert-butyloxycarbonyl, TMS trimethylsilyl, Ts tosyl.

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