Table 1 Optimization of reaction conditions^a

DME dimethyl ether, DMA N,N-dimethylacetamide, acac acetylacetonate, OTf triflate, COD 1,5-cyclooctadiene, DMSO dimethyl sulfoxide, EtOAc ethyl acetate, TDAE tetrakis(dimethylamino)ethylene.
^aReaction conditions: 1a (0.2 mmol), 2a (0.3 mmol), 3a (0.6 mmol), Ni catalyst (10 mol%), ligand (12 mol%), reductant (0.6 mmol), solvent (1 mL), 25 °C, 24 h, N₂ atmosphere.
^bLigand (20 mol%) was used.
^c1a (0.3 mmol), 2a (0.2 mmol) were used.
^dThe reaction run at 35 °C for 36 h.
^eThe isolated yield was shown in parentheses on 0.4 mmol scale.
^f(3-iodopropyl)benzene as the substrate.

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