Fig. 7: Model. | Nature Communications

Fig. 7: Model.

From: Sphingosine 1-phosphate mediates adiponectin receptor signaling essential for lipid homeostasis and embryogenesis

Fig. 7

Membrane rigidification activates a ceramidase activity intrinsic to AdipoR2, resulting in the generation of sphingosine 1-phosphate (S1P) that separately activates the SREBP1 and PPARγ transcription factors. SREBP1 and PPARγ together promote increased transcription of SCD, resulting in increased levels of unsaturated fatty acids and restored membrane fluidity.

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