Fig. 2: Mutation disparity between AYAs and OAs.
From: Genomic disparities between cancers in adolescent and young adults and in older adults
a Mutations (including non-silent substitutions and small insertions/deletions) per coding megabase (Mbs) in AYAs and OAs. Tumor types are ordered by the median mutation rate (red line) in AYAs. Cancer types that show statistical significance (FDR < 0.05) are highlighted in bold. Black and gray lines represent two cutoffs we used to select hypermutators (AYA cutoff: 10.83 mutations/Mb; OA cutoff: 14.56 mutations/Mb). b A summary of clinical factors that underlie differential mutational rates per logistic regression models. c Recurrent genes (n = 13) with different mutational rates (FDR < 0.05). Circle size represent the absolute value of mutation rates differences (AYA-OA). Red indicates higher in AYAs, and blue indicates higher in OAs. d 47 genes with differential mutational rates (FDR < 0.05) in a specific cancer type. Genes with higher mutational rates in AYA are in red, otherwise in blue. e Differences in mutation rates between AYAs and OAs based on GENIE (x axis) and TCGA (y axis) cohorts. Each dot represents one gene-cancer pair that was identified showing different mutational rate between AYA and OA in GENIE data. f TERTp mutational rates in AYAs (blue) and OAs (orange) in 15 tumor types. Asterisk indicates statistically significant difference (FDR < 0.05). Source data are provided as a Source Data file.
