Fig. 4: Gene ontology (GO) and Kyoto Encyclopaedia of Genes and Genomes (KEGG) enrichment analyses for genes annotated to CpGs with a p < 1.0 × 10−5 and enriched trait associations in the EWAS Atlas for the individual CpGs. | Nature Communications

Fig. 4: Gene ontology (GO) and Kyoto Encyclopaedia of Genes and Genomes (KEGG) enrichment analyses for genes annotated to CpGs with a p < 1.0 × 10−5 and enriched trait associations in the EWAS Atlas for the individual CpGs.

From: Epigenome-wide meta-analysis identifies DNA methylation biomarkers associated with diabetic kidney disease

Fig. 4: Gene ontology (GO) and Kyoto Encyclopaedia of Genes and Genomes (KEGG) enrichment analyses for genes annotated to CpGs with a p < 1.0 × 10−5 and enriched trait associations in the EWAS Atlas for the individual CpGs.The alternative text for this image may have been generated using AI.

The size of the points reflects the number of differentially methylated genes associated with each term (panel a and b) or the number of CpGs identified for this phenotype in the EWAS Atlas (panel c). The colour gradient reflects the association strength. The y-axis shows −log10(p-values). The dotted line corresponds to p = 0.05 and p-values were derived from a hypergeometric test implemented in the missMethyl R package. TNFR2 tumour necrosis factor receptor 2, GGT Gamma−glutamyl transferase (GGT), eGFR estimated glomerular filtration rate, TEA Trait enrichment analysis, P phosphorus.

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