Fig. 5: Selected differentially upregulated genes in high-IL6/R pAML samples.

a Samples with RAS/FLT3 point mutations and co-occurring Inv(16). b Samples with NUP98 translocations and RAS/FTL3 point mutations. c Samples carrying ML-rearrangements with or without mutations in the growth factor signaling associated genes FLT3 and RAS (“indicated as “GF” and “noGF” respectively). For all 3 panels, all within-group pairwise two-sided comparison Mann–Whitney U Test P values are <0.05. The abbreviations “hiIL6” and “loIL6” indicate the high-IL6/R and low-IL6/R pAML subtypes. Numbers of samples per group: NBM = 45, low-IL6/R = 306, hiIL6 Inv16 GF = 17, loIL6 Inv16 GF = 11, hiIL6 NUP98 GF = 20, loIL6 NUP98 GF = 12, hiIL6 MLL GF = 53, loIL6 MLL GF = 13, hiIL6 MLL noGF = 46, loIL6 MLL noGF = 24. Boxplots show the median and the upper and lower central-quartiles. The expected range of the data is indicated by whiskers.