Fig. 6: TLR4 and S100A8/9 are expressed at higher levels in high-IL6/R samples compared to low-IL6/R, but not NBM. | Nature Communications

Fig. 6: TLR4 and S100A8/9 are expressed at higher levels in high-IL6/R samples compared to low-IL6/R, but not NBM.

From: Inflammatory bone marrow signaling in pediatric acute myeloid leukemia distinguishes patients with poor outcomes

Fig. 6: TLR4 and S100A8/9 are expressed at higher levels in high-IL6/R samples compared to low-IL6/R, but not NBM.

a TLR4 and S100A8/9 expression levels in MLL-rearranged AML with or without RAS/FLT3 mutations (indicated as “GF” and”no-GF” respectively), and b TLR4 and S100A8/9 expression levels in NUP98-rearranged and Inv(16) AML with RAS/FLT3 mutations. Numbers of samples per group: hiIL6 Inv16 GF = 17, loIL6 Inv16 GF = 11, hiIL6 NUP98 GF = 20, loIL6 NUP98 GF = 12, hiIL6 MLL GF = 53, loIL6 MLL GF = 13, hiIL6 MLL noGF = 46, loIL6 MLL noGF = 24. Boxplots show the median and the upper and lower central-quartiles. The expected range of the data is indicated by whiskers.

Back to article page