Fig. 2: Overview of crystal structure of L1 from S. maltophilia in a complex with hydrolyzed moxalactam.
From: Time-resolved β-lactam cleavage by L1 metallo-β-lactamase
a Structure of L1 is shown as cartoon (salmon), active site contains moxalactam (green sticks), and two zinc ions are showed in yellow. Bottom surface depicts the Coulombic electrostatic potential plotted on the surface of the L1 in complex with moxalactam at 295 K (electrostatic potential calculated using default settings in UCSF Chimera). b Cartoon representation of L1 MBL superposed with crystal structures of B1, B2, and B3 subclasses of MBLs depicted as licorice models. Crystal structure of L1 MBL determined at room temp using SSX (PDB entry 7L52 - magenta) was superimposed with structures of MBL representatives: B1 subclass NDM-1 from K. pneumoniae (PDB entry 6TWT - cyan), B2 subclass mono-zinc MBL SFH-I from Serratia fonticola (PDB entry 3SD9 - yellow), B3 subclass FEZ-1 MBL from Legionella gormanii (PDB entry 5WCK - gray), two zinc ions are showed in pink. c Comparison of key residues in the active site of MBL subclasses. Zinc atoms showed as pink spheres, water molecules are depicted as red spheres with a small radius.
