Fig. 6: Pharmacokinetics and biodistribution of HPNAs. | Nature Communications

Fig. 6: Pharmacokinetics and biodistribution of HPNAs.

From: Hybrid chalcogen bonds in prodrug nanoassemblies provides dual redox-responsivity in the tumor microenvironment

Fig. 6: Pharmacokinetics and biodistribution of HPNAs.The alt text for this image may have been generated using AI.

Pharmacokinetic profiles of the (a) prodrugs, (b) released DTX, and (c) total equivalent DTX. All data of a–c were presented as mean ± SD (n = 3 rats). Source data are provided as a Source Data file. d Biodistribution of DiR-solution or DiR-labeled HPNAs. Quantitative analysis of biodistribution at 4 h (e) and 12 h (f). g The accumulated DTX of Taxotere and HPNAs in tumor. All data of e–g were presented as mean ± SD (n = 3 mice). n.s (no significance) P > 0.05, *P < 0.05, **P < 0.01, and ***P < 0.001 by two-tailed Student’s t-test. Source data are provided as a Source Data file.

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