Fig. 2: Multiple viral cDNA probe detections indicate that HTLV-1 presents exclusively in all the peripheral blood and tissues of aGVHD patients. | Nature Communications

Fig. 2: Multiple viral cDNA probe detections indicate that HTLV-1 presents exclusively in all the peripheral blood and tissues of aGVHD patients.

From: HTLV-1 infection of donor-derived T cells might promote acute graft-versus-host disease following liver transplantation

Fig. 2

A The heatmap depicts the detection of virus or virus/host integration in each sample from two patients in the aGVHD group and 17 patients in the control group. Negative, positive, and host integration results are marked as blue, yellow, and red, respectively. B Patient numbers of virus infection and host integration were counted. C The percentages of virus infection rates in each group were calculated and compared between the aGVHD group (N = 2) and control group (N = 17). All p values were calculated using Fisher’s exact test and corrected with Benjamini-Hochberg adjustment. *p = 0.0406. D The percentage of patients with virus detected in either peripheral blood or tissue samples. E The heatmap depicts basic clinical information of the 400 patients in the validation cohort, which includes age, body mass index (BMI), sample collection time, pre-operative diagnosis, and concomitant diseases. The two HTLV-1 infection patients are marked by red arrows with annotations of the viral loads. (Benign ESLD: benign end-stage liver disease, Malignant LD: malignant liver disease, Complications after LT: complications after liver transplantation, NC: no concomitant disease.).

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