Fig. 6: MBOAT7 remodels the inflammation related chromatin landscape and the suppressive histone landscape. | Nature Communications

Fig. 6: MBOAT7 remodels the inflammation related chromatin landscape and the suppressive histone landscape.

From: A metabolic associated fatty liver disease risk variant in MBOAT7 regulates toll like receptor induced outcomes

Fig. 6

a Scheme illustrating the experimental design. b Heatmap showing relative expression of the subset of inflammatory and immune response genes. c Gene ontology categories enriched in the subset of MBOAT7 depletion-induced repressed and induced genes. d Ingenuity pathways analysis (IPA, Ingenuity systems). e Heatmap of ATAC-seq (±2 kb from peak centre) in MDM transfected with MBOAT7 siRNA or control. f Gene ontology categories enriched in the subset of MBOAT7 depletion-induced differential peaks in the ATAC-seq. g Browser tracks showing ATAC-seq data at indicated loci. Peaks are highlighted by black boxes. h Transcription factor (TF) motifs enriched in chromatin regions showing increased accessibility on MBOAT7 depletion. i Browser tracks showing ATAC-seq data at EZH2 locus. j Heatmap of H3K27me3 Cut&tag (±2 kb from peak centre) in MDM transfected with MBOAT7 siRNA or control. k Browser tracks showing H3K27me3 at SOCS2. l TF binding motifs enriched at sites of MBOAT7 depletion-induced differential peaks enrichment in H3K27me3.

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