Fig. 7: C16-induced conformational changes.
From: Cannabinoid non-cannabidiol site modulation of TRPV2 structure and function
Overlay of the (a-c) TRPV2C16-2 (dark green) and TRPV2apo-1 (PDB-ID: 6U84, pink) and (d-f) TRPV2C16-2 (dark green) and TRPV2PLG (PDB-ID: 6WKN, purple) structures based on global tetramer alignment. a-c Membrane views of TRPV2C16-2 and TRPV2apo-1 showing (a) two opposite S5-PH-S6 units, (b) a single subunit (S1-S5) and an adjacent subunit (showing S5-PH-S6-TRP helix), and (c) the local changes around the suggested C16 binding site. d-e Membrane views similar to a-c comparing TRPV2C16-2 and TRPV2PLG. Arrows indicate movements of TRPV2C16-2 relative to TRPV2apo-1 and TRPV2PLG, respectively. Local conformational changes are highlighted with stars. C16 is displayed as pink sticks in b, c and e, f.
