Fig. 3: SSOE accelerates corneal epithelial wound healing after alkali burn.
From: Perfluorodecalin-based oxygenated emulsion as a topical treatment for chemical burn to the eye
a Schematic depicting ocular alkali burn in mice: a 2-mm circular filter paper soaked with 1 M sodium hydroxide (NaOH) was applied to the center of the right eye for 20 s, followed by copious irrigation till the pH level returned to normal. SSOE or unoxygenated vehicle control were then immediately applied to the eye for 40 min. b Fluorescein staining (green color when photographed with Cobalt blue filter) highlights corneal epithelial defects at 24 h and superficial punctate keratitis at 48 h after burn. SSOE moderately accelerated wound closure at 24 h (c) and reduced superficial punctate staining at 48 h (d). Data are presented as mean ± SEM. Twenty-four-hour timepoint: n = 20, 24, 23 eyes in untreated, vehicle, and SSOE-treated groups, respectively; 48 h: n = 20, 27, 23 eyes in untreated, vehicle and SSOE-treated groups, respectively. Statistical significance was determined using one-way ANOVA with Tukey’s multiple comparisons test (two-sided). Data were summarized from seven independent experiments. Source data are provided as a Source Data file.
