Fig. 3: QCDPred assignment of TMDs as QCAP degrons.
From: Conserved degronome features governing quality control associated proteolysis
a Map of degrons prediction by QCDPred and TMDs prediction by TMHMM within Pca1. Marked by an arrowhead is the Pca1 cytosolic degron. A degron cutoff probability is marked at P = 0.85 by a dashed gray line. b Venn diagram of the relationship between yeast TMDs, extracted from the TM Helix Hidden Markov Model (TMHMM) algorithm, and QCDPred degron probabilities of the entire yeast proteome (P ≥ 0.85). c Assignment of QCDPred calculated degrons (in green) and TMHMM predicted TMDs (in yellow) to the cytochrome b-c1 complex (PDB #6T0B70). overlay regions are colored in orange. d Frequency distribution of (i) all QCDPred assigned degrons within the yeast proteome (P ≥ 0.85), (ii) QCDPred assigned degrons within the yeast proteome composed of TMDs, and (iii) QCDPred assigned degrons within the yeast proteome that are not part of a TMD, sorted into probability ranges between 0.85 −1.
