Fig. 4: GMT antibody landscapes by exposure history.
From: BA.2 and BA.5 omicron differ immunologically from both BA.1 omicron and pre-omicron variants
The colored surfaces represent the GMT antibody landscapes of the different serum groups. The map shown in Fig. 3 serves as base plane, the z-axis reflects log2 titers with each two-fold increase marked starting from titer 20. The grey plane at titer 50 serves as reference. The GMT antibody landscapes were grouped and colored by virus exposures: Panel a. Single exposure convalescent sera (from top to bottom: delta (orange), ancestral virus (blue), beta (yellow), BA.2 omicron (purple), alpha (green), and BA.1 omicron (red)). Panel b. Two close exposures (from top to bottom: ChAdOx-S1/BNT162b2 (AZ/BNT), BNT162b2/BNT162b2 (BNT/BNT), mRNA-1273/mRNA-1273, ChAdOx-S1/ChAdOx-S1 (AZ/AZ)). Panel c. Two distant exposures (from top to bottom: pre-omicron infection followed by BA.2 omicron reinfection (BA.2 reinf., pink), pre-omicron infection followed by BA.2 omicron reinfection (BA.1 reinf., red)). Panel d. Three or more close exposures (from top to bottom: BNT/BNT + delta breakthrough (BNT/BNT + delta, light brown), three dose BNT vaccination (BNT/BNT/BNT, dark grey), AZ/AZ + delta breakthrough (AZ/AZ + delta, orange)). Panel e. Three or more distant exposures (from top to bottom: Vacc + BA.2 omicron breakthrough (Vacc + BA.2, purple), Vacc + BA.1 reinfection (Vacc + pre-omicron breakthrough infection + BA.1 omicron reinfection, red), Vacc + BA.1 omicron breakthrough (Vacc + BA.1, salmon)). Individual sera antibody landscapes are shown in Fig. S11.
