Fig. 4: Hepatic metabolomic and lipidomic profiles in mice fed a 18% protein diet or a 1% protein diet with and without NAM treatment.

a sPLS-DA and correlation circle plots of hepatic central carbon metabolism showing separation of 18 and 1% protein-diet group (n = 5 per group). b sPLS-DA and correlation circle plots of hepatic central carbon metabolism showing separation of 1% protein diet and NAM-treated group (n = 5 for 1%; n = 7 for 1%+NAM). c sPLS-DA and correlation circle plots of hepatic lipidomics showing separation of 18 and 1% protein-diet group (n = 6 per group). d sPLS-DA and correlation circle plots of hepatic lipidomics showing separation of 1% protein diet and NAM-treated group (n = 6 per group).